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Global Tangential Flow Filtration Market Report 2023: Advantages Over Standard Or Normal Flow Filtration Driving Adoption -


DUBLIN–(BUSINESS WIRE)–The “Global Cross-flow Filtration Market Size, Share and Trend Analysis Report by Technology (Microfiltration, Ultrafiltration, and Nanofiltration and Others), by Product, by Application, by End User, by Outlook and regional forecasts, 2022 – The 2028 report” has been added to from offer.

The global tangential flow filtration market size is expected to reach USD 3.5 billion by 2028, growing the market at 10.9% CAGR during the forecast period.

Market Growth Factors

Providing more benefits over standard or normal flow (Nff) filtration

Some important advantages offered by tangential flow filtration are higher flow rates, increased productivity and less filter cake development have increased the use of TFF in various industries. TFF used as a single-use method also helps reduce cross-contamination of the finished product with any retentate. This approach gave rise to an improved version of the current TFF technology known as once-through TFF.

Growing need for protein separation for the preparation of recombinant proteins

Many scientific disciplines, including protein chemistry, immunology, DNA/RNA/molecular oligonucleotides, biochemistry and microbiology, have used tangential flow filtration techniques. The primary use of TFF in these industries is to fractionate dilute protein mixtures, to desalt and concentrate peptides and proteins, and to recover and purify recombinant proteins or antibodies from cell culture media. TFF’s ability to perform highly efficient diafiltration and concentration processes enables precise separation of intact biomolecules.

Market restraining factor

High initial flux in microfiltration membranes

A significant disadvantage of tangential flow filtration systems is the high initial flow. This is particularly important in TFF microfiltration membranes. The initial flow hampers the carrier volume of subsequent flows and can quickly foul the membrane. As a result, transmembrane pressure control becomes very important, which is only sometimes possible. The high initial flux also decreases the overall flux rate.

Product outlook

On the basis of product, the tangential flow filtration market is categorized into single-use tangential flow filtration systems, reusable tangential flow filtration systems, membrane filters, and filtration accessories. Single use TFF systems have acquired significant growth rate in the tangential flow filtration market in 2021. Single use TFF systems are preferred and used by several companies, contract manufacturing organizations and contract research organizations . These are also used in research and academic studies. This system offers benefits such as a smaller footprint, reduced cross-contamination and significantly reduced processing time for the entire batch.

Technology outlook

On the basis of technology, the tangential flow filtration market is classified into ultrafiltration, microfiltration, nanofiltration and others. Microfiltration segment generated the maximum revenue share in the tangential flow filtration market in 2021. The pore size of these membranes ranges between 0.1 and 10 micrometers and they are widely used in protein fractionation , pre-treatment of other membranes and microbial removal. The increased use of microfiltration processes in cell separation methods is the main growth driver for this segment.

Application Outlook

On the basis of application, the tangential flow filtration market is fragmented into protein purification, vaccines and viral vectors, antibody purification, raw material filtration, etc. The protein purification segment has acquired the highest revenue share in the tangential flow filtration market in 2021. The growth of the segment is attributed to the growing need and usage of recombinant proteins. TFF is used to concentrate and desalt peptides and proteins to recover and purify antibodies.

End User Outlook

Based on end-user, the tangential flow filtration market is segmented into pharmaceutical and biotechnology companies, contract research organizations and contract manufacturing organizations, and academic institutes and research laboratories. The contract research organization (CRO) and contract manufacturing organization (CMO) segment provided considerable growth rate in the tangential flow filtration market in 2021. Rising demand for biopharmaceuticals, increasing adoption of single-use TFF technologies and growing investment are all responsible for the growth of the segment.

Regional outlook

On the basis of region, the tangential flow filtration market is analyzed across North America, Europe, Asia Pacific, and LAMEA. North America segment recorded the maximum revenue share in the tangential flow filtration market in 2021. The government in the region has launched various initiatives and programs that support the extensive use of TFF technology. Increasing research and production capabilities of biopharmaceutical and pharmaceutical companies are further boosting the applications of TFF.

Main market players

List of companies featured in the report:

  • Parker Hannifin Corporation

  • Danaher Corporation

  • Sartorius Stedim Biotech SA (Sartorius AG)

  • Merck Millipore (Merck Group)

  • Alfa Laval AB

  • Repligen Corporation

  • Meissner Filtration Products, Inc.

  • ABEC, Inc.

  • Sterlitech Corporation

  • Synder Inc.

Main topics covered:

Chapter 1. Market Scope and Methodology

Chapter 2. Market Overview

Chapter 3. Global Cross-flow Filtration Market by Technology

Chapter 4. Global Cross-flow Filtration Market by Product

Chapter 5. Global Cross-flow Filtration Market by Application

Chapter 6. Global Tangential Flow Filtration Market by End User

Chapter 7. Global Cross-flow Filtration Market by Region

Chapter 8. Business Profiles

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